COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR
“CLINICAL EVALUATION OF INDRASHANI CHOORNA IN MANAGEMENT OF
PANDU W. S. R TO IRON DEFICENCY ANAEMIA”
Dr. KAVERI. V. RAM B.A.M.S
DEPT. OF P.G. STUDIES IN KAYACHIKITSA
A.L.N.RAO MEMORIAL AYURVEDIC MEDICAL COLLEGE AND P.G. CENTRE KOPPA – 577126
Dr. DEBAJIT BHATTACHARYYA M.D (Ayu)
PROFFESSOR AND HEAD OF DEPT. OF P.G. STUDIES IN KAYACHIKITSA, A.L.N.RAO MEMORIAL AYURVEDIC MEDICAL COLLEGE AND P.G. CENTRE KOPPA – 577126
A.L.N.RAO MEMORIAL AYURVEDIC MEDICAL COLLEGE AND P.G. CENTRE
CHIKMAGALUR DISTRICT, KARNATAKA
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION
Permanent Address : DR.KAVERI.V.RAM
D/O K.SIVARAMAN NARMADA BHAVAN SASTHAMCOTTA (P.O) KOLLAM (DIST)
6.1NEED FOR STUDY:
Anaemia is a condition in which the Haemoglobin content of the blood is lower than normal as a result of a deficiency of one or more essential nutrients regardless of the cause of such deficiency1. If the same is resulted by deficiency of iron it is called as Iron Deficiency Anaemia(IDA)2. Anaemia is most prevalent in the under developed and developing countries especially in the economically backward and working class people, due to the nutritional deficiency and unhygienic food. The incidence of anaemia is highest among women and children, varying between 60 – 70%. Iron Deficiency Anaemia is the most common type of anaemia worldwide. In developed countries, one third of the women in their child bearing age suffer from Iron Deficiency Anaemia3.
In Ayurveda Iron Deficiency Anaemia can be considered as Panduroga as it displays many features in common with a collection of signs and symptoms that are typically diagnosed as Iron Deficiency Anaemia. The cardinal feature of Panduroga is Pandutwa. According to Acharya Charaka, it is one among the Rasavaha Srotodushti Lakshanas4 and according to Acharya Sushrutha as one among the Raktavaha Srotodushti Lakshanas5. Anaemia in moderate form, presents itself with symptoms like fatigue, loss of appetite, weakness, breathlessness and palpitation particularly with physical exertion and pallor of the skin and the mucous membrane. Further Iron Deficiency may impair cellular responses and immune functions to become susceptible to infections.
Number of single drugs and formulations has been attempted by research initiatives seeking holistic management of Panduroga, still there is a scope for innovative, safer and cost- effective formulation in the disease management.
For the present study, “Indrashani Choorna” mentioned in Choorna prakarana of Sahasrayoga, has been selected, which comprises of Tila, Pippali, Badara, Madhu, Makshika, Ayas, Shunthi and Sita6. The research hypothesis is that, “Indrashani choorna” is helpful in the management of Panduroga w.s.r. to Iron deficiency Anaemia.
A thorough review of classical Ayurvedic texts including Brihatrayee and Laghutrayee, shall be made to collect all the relevant data and information relating to the study. Present time journals including websites and contemporary medical books also shall be referred for the study.
Some of the research works done on Panduroga are:
A complete review of all the classical literatures & contemporary system of medicine bearing the description related to the disease Panduroga (IDA) shall be made, so as to obtain the theoretical data for the present study, also review of all the relevant literatures shall be made to obtain references related to the formulation w.r.t the preparation, dosage etc., required for the study.
The formulation Indrashani Choorna selected for the present research work shall be prepared in the pharmacy attached to A. L. N. Rao Memorial Ayurveda Medical College and Hospital, Koppa as per the textual reference.
Patients of either sex attending OPD and IPD of A. L. N. Rao Memorial Ayurveda Medical College and Hospital, Koppa and its associated Hospitals who are diagnosed as Panduroga (IDA) will be selected for study.
For the present study 30 patients of either sex of age group 16-60yrs diagnosed as Panduroga (IDA) will be selected from OPD and IPD of A. L. N. Rao Memorial Ayurveda Medical College Hospital, Koppa and its associated Hospitals. The patients will be selected strictly abiding to the inclusion and exclusion criteria. The patients thus selected will be grouped into a single trial group, of group size 30.
The trial group will be administered “Indrashani Choorna”, 2gm twice daily before food (morning and night) and the duration of the treatment will be 30 days. The ingredients of the formulation will be properly identified by respective department of the institution.
The subjective parameters for assessment of the present study will be the classical lakshanas of Panduroga (IDA) according to Ayurvedic texts i.e. Panduta, Arohanayasa, Hriddrava, Shrama, Gourava, Bhrama, Aruchi, Agnimandya and Dourbalya. The objective parameters for assessment will be laboratory investigations of blood for Haemoglobin percentage and Peripheral Blood smear.
The patient will be thoroughly assessed through the subjective parameters as well as objective parameters, the detailed history and examination findings will be noted before, during and after the scheduled treatment. The changes in signs and symptoms will be documented at an interval of 15 days in a specially designed Case Proforma.
Study Design: Standard single blind clinical study with pre trial and post trial design is adopted.
|Sample size||30 patients|
|Dose||2mg twice daily before food|
|Total Duration||30 days|
The classical Laxanas of Panduroga namely Panduta, Arohana ayasa, Shrama, Gourava, Bhrama , Aruchi and Agnimandya.
Haemoglobin percentage, and peripheral blood smear (IDA). The scoring will be given for the subjective and objective parameters. The assessment will be done on the basis of result obtain from statistical analysis done by paired student ‘t’ test.
Yes, the study will be a human clinical study
|Sample size||30 patients|
|Dose||2 mg twice daily before food|
|Total Duration||30 days|
Has ethical clearance been obtained from your institution in case of 3?
Yes, the ethical clearance has been obtained through the ethical committee formulated in the institution.